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KMID : 1007520130220051449
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Food Science and Biotechnology
2013 Volume.22 No. 5 p.1449 ~ p.1452
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Flaniostatin, a New Isoflavonoid Glycoside Isolated from the Leaves of Cudrania tricuspidata as a Tyrosinase Inhibitor
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Kang Young-kyoung
Choi Jeong-Un
Lee Eun-Ah
Park Hae-Ryong
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Abstract
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In the course of screening program for skin whitening compounds, flaniostatin (FST) was isolated from the leaves of Cudrania tricuspidata as a novel inhibitor of tyrosinase. The structure of FST was determined by ESI-MS and NMR spectroscopic analyses as a new isoflavone glycoside. The FST was exhibited a tyrosinase inhibitory effect in a dose-dependent manner. This effect was higher than that of arbutin at the same concentrations. These results indicated that FST isolated from C. tricuspidata may be a positive tool for skin-whitening agent research.
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KEYWORD
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tyrosinase, Cudrania tricuspidata, isoflavonoid glycoside, flaniostatin
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